| From the Northeast via the New Jersey Turnpike South |
| Use Exit 4. Bear right out of the toll following signs for NJ-73 N and merge onto NJ-73 N. Slight left onto NJ-90 W (signs for Betsy Ross Bridge). Keep left at the fork, follow signs for I-95 S/Central Phila and merge onto I-95 S. Take exit 22 toward I-676 W/US-30. Merge onto Vine St Expy. Continue onto I-676 N. Keep right at the fork, follow signs for I-76 E/International Airport and merge onto I-76 E. Take exit 346A on the left for South St. Turn right onto South St. South St turns slightly left and becomes Spruce St. Go one block and Irvine Auditorium followed by Houston Hall is on the right. |
| From the North via I-95 South |
Take exit 22 toward I-676 W/US-30. Merge onto the Vine Street Expressway. Continue onto I-676 N. Keep right at the fork, follow signs for I-76 E/International Airport and merge onto I-76 E. Take exit 346A on the left for South St. Turn right onto South St. South St turns slightly left and becomes Spruce St. Go one block and Irvine Auditorium followed by Houston Hall is on the right.
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| From the West via the Pennsylvania Turnpike |
| On the PA turnpike, take exit 326 to merge onto I-76 E towards Philadelphia. Follow signs for I-76 E. Take exit 346A on the left for South Street. At the top of the ramp, turn right onto South Street. South Street becomes Spruce Street. Go one block and Irvine Auditorium followed by Houston Hall is on the right. |
| From the South via I-95 North |
| While on I-95 N, take exit 13 to merge onto PA-291 E toward I-76 W/Valley Forge. Turn left onto S 26th St. Take the ramp onto I-76 W. Take exit 346A on the left for South Street. Turn left onto South St. South St turns slightly left and becomes Spruce St. Go one block and Irvine Auditorium followed by Houston Hall is on the right. |
